Download Advances in Virus Research, Volume 88 by Karl Maramorosch, Frederick A. Murphy PDF

By Karl Maramorosch, Frederick A. Murphy

The first evaluate sequence in virology and released given that 1953, Advances in Virus Research covers a various diversity of in-depth experiences, offering a useful assessment of the sector.

  • Contributions from best authorities
  • Comprehensive studies for common and expert use
  • First and longest-running evaluate sequence in virology

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2011). , 2013). The authors identified 102 mosquito– DENV protein–protein interactions involving C, NS3, NS5, and prM. Interactions with NS3 were enriched in proteins implicated in response to stress and heat shock, while the C-interactants were enriched in nucleic acid-binding proteins. , 2013). Computational models are of increasing importance to integrate the multiple virus–host interactions into a network that allows predictions of biological reactions. , 2010). Doolittle and colleagues used protein structural similarity as well as published results from siRNA screens to establish a network of putative interactions between DENV proteins and proteins from mosquito and human hosts.

2010). Doolittle and colleagues used protein structural similarity as well as published results from siRNA screens to establish a network of putative interactions between DENV proteins and proteins from mosquito and human hosts. Interestingly, the authors observed enrichment for proteins involved in stress response, UPR and IFN pathways. Examples of interactions related to ER stress/apoptosis include NS4B with GADD34 and NS2A, NS4B, and C with NYFA (a protein involved in ATF6 pathway) and E with BCL-2.

1999). 44 Eliana G. Acosta et al. With the aim to identify the DENV receptor, Reyes-Del Valle and coworkers applied an affinity chromatography purification using the E glycoprotein as a ligand and isolated the chaperons HSP70 and HSP90 as components of the DENV receptor complex (Reyes-Del Valle, Chavez-Salinas, Medina, & Del Angel, 2005). , 2005). , 1999). Unfortunately, this hypothesis has never been corroborated. Other reports postulated that HSP70/HSP90 would be required for DENV infection of human monocytes/macrophages but are dispensable for infection of liver cells.

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