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By Yvonne A. Barnett

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266, 8663–8666. 35. Pendergrass, W. , Saulewicz, A. , and Norwood, T. H. (1994) Murine temperature-sensitive DNA polymerase alpha mutant displays a diminished capacity to stimulate DNA synthesis in senescent human fibroblast nuclei in heterokaryons at the nonpermissive condition. J. Cell. Physiol. 158, 270–276. 36. Pendergrass, W. , Angello, J. , Saulewicz, A. , and Norwood, T. H. (1991) DNA polymerase alpha and the regulation of entry into S phase in heterokaryons. Exp. Cell Res. 192, 426–432.

And Deamond, S. F. (1991) Longitudinal study of in vivo wound repair and in vitro cellular senescence of dermal fibroblasts. Exp. Gerontol. 26, 17–27. 79. Deamond, S. F. and Bruce, S. A. (1991) Age-related differences in the promoterinduced extension of in vitro proliferative life span of syrian hamster fibroblasts. Mech. Ageing Dev. 60, 143–152. 80. Cristofalo, V. , Allen, R. , Pignolo, R. , Martin, B. , and Beck, J. C. (1998) Relationship between donor age and the replicative life spans of human cells in culture: a re-evaluation.

1997) Induction of a G2-phase arrest in Xenopus egg extracts by activation of p42 mitogen-activated protein kinase. Mol. Biol. Cell 8, 2157–2169. 48 Cristofalo, Volker, and Allen 61. , Lin, A. , McCurrach, M. , and Lowe, S. W. (1997) Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16ink4a. Cell 88, 593–602. 62. Rohme, D. (1981) Evidence for a relationship between longevity of mammalian species and life spans of normal fibroblasts in vitro and erythrocytes in vivo.

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