Download Antibodies, Antigens, and Molecular Mimicry by John J. Langone (Eds.) PDF

By John J. Langone (Eds.)

The severely acclaimed laboratory ordinary, Methods in Enzymology, is likely one of the such a lot hugely revered courses within the box of biochemistry. seeing that 1955, each one quantity has been eagerly awaited, usually consulted, and praised by way of researchers and reviewers alike. The sequence includes a lot fabric nonetheless proper this present day - really an important book for researchers in all fields of lifestyles sciences

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Balch, and H. Wanebo, Am. Surg. 52, 148 (1986). 77 G. G. Stevenson and F. K. Stevenson, Immunopathology6, 99 0983). 78 R. K. Oldham, K. A. Foon, A. C. Morgan, C. S. Woodhouse, R. W. Schroff, P. G. Abrams, M. Fer, C. S. Schoenberger, M. Farrell, E. Kimbell, and S. A. Sherwin, J. Clin. Oncol. 2, 1235 (1984). 79 A. N. Houghton, D. Mintzer, C. Cordon-Cardo, S. Welt, B. Fliegel, S. Vadhan, E. Carswell, M. R. Melamed, H. F. Oettgen, and L. J. Old, Proc. Natl. Acad. Sci. A. 82, 1242 (1985). 8o T. Tai, L.

KOhler, Science 240, 1034 (1988). m W. V. Williams, H. R. Guy, D. H. Rubin, F. Roby, J. N. Myers, T. Kieber-Emmons, D. B. Weiner, and M. I. Greene, Proc. Natl. Acad. Sci. A. 85, 6488 (1988). 28 IDIOTYPES, ANTI-IDIOTYPES, AND MOLECULAR MIMICRY [1] tially antigenic, with epitope domains being associated with highly variable residue positions. This relationship between sequence variation and surface epitope expression has led to a statistical approach to identify variable domains that are restricted to the protein s u r f a c e J 4° The potential antigenic variability and the expression of idiotopes by immunoglobulins has been demonstrated by the application of this approach.

Top. Microbiol. lmmunol. 57 (1985). 63 W. Lee, H. Cosenza, and H. K6hler, Nature (London) 247, 55 (1974). 64 j. Quintans, M. R. -S. Quan, R. F. Dick, and B. Regueiro, Eur. J. lmmunol. 11, 236 (1981). 65 M. K. Wittner, M. A. Bach, and H. K6hler, J. Immunol. 128, 595 (1982). E. Trenkner and R. Riblet, J. Exp. Med. 142, 1121 (1975). [1] IDIOTYPIC NETWORKS AND MOLECULAR MIMICRY 13 T15 antibodies were able to induce in vitro an anti-PC plaque-forming cell (PFC) response in the absence of the antigen.

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